NetCrafter is an intuitive platform for constructing functional gene networks using biological ontologies and curated knowledgebases. It enables users to build biologically meaningful networks from either a simple list of genes or from genes combined with omics data - without relying on prior gene–gene interaction data.

NetCrafter quantifies shared biological functions among genes using resources such as the Gene Ontology (GO), Human Phenotype Ontology (HPO), Hallmark genesets and Oncogenic Signature collections, allowing users to contextualize their results within well-established functional and disease-related frameworks.

>> See details of NetCrafter ontologies

This ontology-based scoring enables the creation of networks that reflect functional similarity and highlight key gene clusters (hotspots) related to biological pathways or disease phenotypes.

In addition, NetCrafter offers interactive ontology clustering and supports the integration of multiple datasets, making it a powerful tool for exploring gene functions, interpreting omics data, and identifying potential biomarkers or therapeutic targets.